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Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study.

TitleFunctional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study.
Publication TypeJournal Article
Year of Publication2022
AuthorsMayer KP, Palakshappa JA, Peltan IDaniel, Andrew JS, Gundel SJ, Ringwood NJ, Mckeehan J, Hope AA, Rogers AJ, Biehl M, Hayden DL, Caldwell E, Mehkri O, Lynch DJ, Burham EL, Hough CL, Jolley SE
Corporate AuthorsNHLBI PETAL Network
JournalPilot Feasibility Stud
Volume8
Issue1
Pagination212
Date Published2022 Sep 19
ISSN2055-5784
Abstract

INTRODUCTION: We describe a protocol for FIRE CORAL, an observational cohort study that examines the recovery from COVID-19 disease following acute hospitalization with an emphasis on functional, imaging, and respiratory evaluation.METHODS AND ANALYSIS: FIRE CORAL is a multicenter prospective cohort study of participants recovering from COVID-19 disease with in-person follow-up for functional and pulmonary phenotyping conducted by the National Heart, Lung and Blood Institute (NHLBI) Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. FIRE CORAL will include a subset of participants enrolled in Biology and Longitudinal Epidemiology of PETAL COVID-19 Observational Study (BLUE CORAL), an NHLBI-funded prospective cohort study describing the clinical characteristics, treatments, biology, and outcomes of hospitalized patients with COVID-19 across the PETAL Network. FIRE CORAL consists of a battery of in-person assessments objectively measuring pulmonary function, abnormalities on lung imaging, physical functional status, and biospecimen analyses. Participants will attend and perform initial in-person testing at 3 to 9 months after hospitalization. The primary objective of the study is to determine the feasibility of longitudinal assessments investigating multiple domains of recovery from COVID-19. Secondarily, we will perform descriptive statistics, including the prevalence and characterization of abnormalities on pulmonary function, chest imaging, and functional status. We will also identify potential clinical and biologic factors that predict recovery or the occurrence of persistent impairment of pulmonary function, chest imaging, and functional status.ETHICS AND DISSEMINATION: FIRE CORAL is approved via the Vanderbilt University central institutional review board (IRB) and via reliance agreement with the site IRBs. Results will be disseminated via the writing group for the protocol committee and reviewed by the PETAL Network publications committee prior to publication. Data obtained via the study will subsequently be made publicly available via NHLBI's biorepository.STRENGTHS AND LIMITATIONS OF THE STUDY: Strengths: First US-based multicenter cohort of pulmonary and functional outcomes in patients previously hospitalized for COVID-19 infection Longitudinal biospecimen measurement allowing for biologic phenotyping of abnormalities Geographically diverse cohort allowing for a more generalizable understanding of post-COVID pulmonary sequela Limitations: Selected cohort given proximity to a participating center Small cohort which may be underpowered to identify small changes in pulmonary function.

DOI10.1186/s40814-022-01151-8
Alternate JournalPilot Feasibility Stud
PubMed ID36123599
PubMed Central IDPMC9483889
Grant ListU01HL123023 / HL / NHLBI NIH HHS / United States
U01 HL123009 / HL / NHLBI NIH HHS / United States
U01HL123008 / HL / NHLBI NIH HHS / United States
3U01HL123009-07S1 / HL / NHLBI NIH HHS / United States
U01HL123004 / HL / NHLBI NIH HHS / United States
3U01HL123009-06S1 / HL / NHLBI NIH HHS / United States
U01HL123010 / HL / NHLBI NIH HHS / United States
U01HL123027 / HL / NHLBI NIH HHS / United States
3U01AT009974-03S1 / AT / NCCIH NIH HHS / United States
U01HL122998. / HL / NHLBI NIH HHS / United States