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The PETAL Network

The Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL Network) is a network of 12 Clinical Centers (CC) and 1 Clinical Coordinating Center (CCC) funded by the National Heart, Lung, and Blood Institute (NHLBI) to develop and conduct randomized controlled clinical trials to prevent or treat, and/or improve the outcome of patients who have, or who are at risk for, Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS).

Participating in Research

The 411 on being a research subject

Lungs 101

Get the basics on the respiratory system

Critical Illness

Terminology and other info explained


Jun 8, 2023

It is with the heaviest of hearts and deepest sorrow that the PETAL Network notes the passing of CCC Biostatistician Douglas Hayden on June 2, 2023.

His obituary can be found on Boston Cremation.

Feb 9, 2022

NHLBI PETAL Network ends Phase 3 sepsis trial early

PETAL Network study found no significant difference in 90-day mortality rates, nor safety concerns, after providing patients with one of two common treatment strategies

Jun 22, 2020

Major US Trial Closes Showing No Benefit for Hydroxychloroquine in COVID-19

June 20, 2020

Mar 3, 2020

On behalf of the PETAL Network, we are excited to share that two of the primary manuscripts have been published in the New England Journal of Medicine.