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Clinicians & Researchers

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Who We Are

The Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL Network) is a network of 12 Clinical Centers (CC) and 1 Clinical Coordinating Center (CCC) funded by the National Heart, Lung, and Blood Institute (NHLBI) to develop and conduct randomized controlled clinical trials to prevent Acute Respiratory Distress Syndrome (ARDS) or provide early treatment to improve the outcome of patients who have ARDS. The PETAL Network is seeking your input and feedback.

EHR Data Collection Center RFP

The PETAL network is preparing to conduct a pragmatic trial investigating different oxygenation targets for patients on mechanical ventilation. This study will access data from the Electronic Health Records (EHR) of 24 of the 50 hospitals that are affiliated with the PETAL network. The project will require extraction of EHR data for mechanically ventilated adults in intensive care units (ICUs) and emergency departments (EDs) during an observational period of several months prior to the trial and then during the 12-month trial. The PETAL Network seeks to fund a sub-contract for an EHR Data Collection Center to lead efforts for extracting data from the EHR of participating hospitals. Please be advised that the approval of this study is pending and an award will only be made if the study is approved.

Please see attached RFP and Survey Application

APPLICATION DEADLINE: September 1st, 2018

- A summary of the COROLLA draft protocol has been posted below.
- A Sample Budget Justification has been posted below
- Proposed Review Criteria for Applications for EHR Data Collection Center has been posted below
- A list of FAQ's in regards to the RFP have been posted below
- Clinical Coordinating Center is requesting a Letter of Intent to Apply before submitting an application. Please forward letters to PETAL Project Manager Nancy Ringwood at

COROLLA Data Collection Center RFP FAQ Session
Mon, Aug 27, 2018 10:00 AM - 11:00 AM EDT
Please join my meeting from your computer, tablet or smartphone.
Link to Webinar

You can also dial in using your phone.
United States: +1 (571) 317-3129
Access Code: 343-650-693 More phone numbers Canada: +1 (647) 497-9391 First GoToMeeting? Let's do a quick system check:

Community Outreach Project

The PETAL Network welcomes future prevention and early treatment trial ideas from the US and international acute care and critical care community.

IPC Committee

Thompson, B. Taylor, MD (Chair) Massachusetts General Hospital (CCC)
Angus, Derek C, MD UPMC Presbyterian
Bienstock, Karen, PA-C NHLBI
Gong, Michelle Ng, MD Montefiore Moses
Hou, Peter C, MD Brigham and Women's Hospital
Park, Pauline K, MD University of Michigan Medical Center
Shapiro, Nate, MD Beth Israel Medical Center
Steingrub, Jay S, MD Baystate Medical Center
Talmor, Daniel, MD Beth Israel Medical Center
Thompson, B. Taylor, MD Massachusetts General Hospital (CCC)
Yealy, Donald M, MD UPMC Presbyterian

An international advisory committee (IAC) has also been formed to facilitate dialog and coordination of research efforts with US and international experts and other clinical trials groups. Plans for their first meeting are in process. Please check back here for updates on their activities.

News & Announcements

Aug 29, 2018

As physicians and scientists, our goal is to advance the care and treatment of sepsis, which claims the lives of more than 250,000 Americans every year. This study compares two approaches for the treatment of septic shock that are both currently in widespread use.

Nov 16, 2017

On May 19th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2015 International Meeting held in Washington, DC.

Dec 19, 2017

On May 18th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2016 International Meeting held in San Francisco, CA.

Dec 17, 2015

It is with the heaviest of hearts and deepest sorrow that the PETAL Network notes the passing of Arthur “Art” P. Wheeler on December 17th, 2015.

read more…

Jul 7, 2015

On May 20th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2015 International Meeting held in Denver Colorado.
Highlights from the presentation:

Feb 9, 2018

Statin therapy does not prevent exacerbations of chronic obstructive pulmonary disease (COPD) or lower mortality from acute respiratory distress syndrome (ARDS), report two studies that rigorously tested the benefit of the cholesterol-lowering drugs on outcomes in the lung diseases.