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Who We Are

The Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL Network) is a network of 12 Clinical Centers (CC) and 1 Clinical Coordinating Center (CCC) funded by the National Heart, Lung, and Blood Institute (NHLBI) to develop and conduct randomized controlled clinical trials to prevent Acute Respiratory Distress Syndrome (ARDS) or provide early treatment to improve the outcome of patients who have ARDS. The PETAL Network is seeking your input and feedback.

Opportunity to be a PETAL Network Site

The PETAL Network is seeking to add new enrolling sites for the upcoming CLOVERS trial. CLOVERS (Crystalloids Liberal or Vasopressors Early Resuscitation in Sepsis) is a Multicenter, prospective Phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. Please note, new sites will be limited to the United States (unfortunately foreign sites cannot apply for this opportunity).

Application Instructions for Interested Sites:

  1. Download and complete the PETAL Network Application document (link is also included below).
  2. Identify an existing Clinical Center (CC) to collaborate with. Each application for a new site must be submitted in collaboration with an existing Clinical Center (CC). This is required due to contractual, monitoring, and reporting procedures. See PETAL Locations for a listing of Clinical Centers.
  3. Those interested are encouraged to contact CC PIs to discuss the potential of joining the Network and CC.
  4. Please submit a single document responding to each section outlined in the application. The document should be no longer than 8 pages (biosketches are not included in these page limits). Email the document to: Nancy Ringwood: NRINGWOOD@mgh.harvard.edu and Katie Oldmixon: COLDMIXON@mgh.harvard.edu
  5. Applications are due March 1, 2018.

For questions, please contact:

Community Outreach Project

The PETAL Network welcomes future prevention and early treatment trial ideas from the US and international acute care and critical care community.

IPC Committee

Thompson, B. Taylor, MD (Chair) Massachusetts General Hospital (CCC)
Angus, Derek C, MD UPMC Presbyterian
Bienstock, Karen, PA-C NHLBI
Gong, Michelle Ng, MD Montefiore Moses
Hou, Peter C, MD Brigham and Women's Hospital
Park, Pauline K, MD University of Michigan Medical Center
Shapiro, Nate, MD Beth Israel Medical Center
Steingrub, Jay S, MD Baystate Medical Center
Talmor, Daniel, MD Beth Israel Medical Center
Thompson, B. Taylor, MD Massachusetts General Hospital (CCC)
Yealy, Donald M, MD UPMC Presbyterian

An international advisory committee (IAC) has also been formed to facilitate dialog and coordination of research efforts with US and international experts and other clinical trials groups. Plans for their first meeting are in process. Please check back here for updates on their activities.

News & Announcements

Feb 9, 2018

Statin therapy does not prevent exacerbations of chronic obstructive pulmonary disease (COPD) or lower mortality from acute respiratory distress syndrome (ARDS), report two studies that rigorously tested the benefit of the cholesterol-lowering drugs on outcomes in the lung diseases.

Dec 19, 2017

On May 18th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2016 International Meeting held in San Francisco, CA.

Nov 16, 2017

On May 19th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2015 International Meeting held in Washington, DC.

Dec 17, 2015

It is with the heaviest of hearts and deepest sorrow that the PETAL Network notes the passing of Arthur “Art” P. Wheeler on December 17th, 2015.

read more…

Jul 7, 2015

On May 20th, PETAL Network investigators presented an update on the Network's activities to attendees of the American Thoracic Society's 2015 International Meeting held in Denver Colorado.
Highlights from the presentation: